Women's Health Research and Novel Perspectives on Sex as an Investigative Variable

• Article type: Research Articles, Short Reports, Methods and Resources, Perspectives and Reviews
• Topics:

• • Education research and innovations on how to include sex as an investigative variable in the teaching of physiology.
  • “How-to” Illuminations articles on teaching physiology research methods including sex as an investigative variable.
  • Laboratory activities on assessing sex as an investigative variable.
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• Article types: Research Articles, Short Reports, Methods and Resources, Perspectives and Reviews

• Topics:
• Sex-induced differences and their outcome to cellular responses: cell signaling, drug response, epigenetics, hormones, innate and adaptive immunity etc.
• Sex-specific biomarkers in in inflammatory, autoimmune and fibrotic diseases.
• Use of big data and artificial intelligence for investigation of cellular sex-dependent responses to external triggers.
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• Article types: Research Articles, Short Reports, Methods and Resources, Perspectives, and Reviews
  
• Topics:

• What parameters that define baseline healthy digestive function are sex-dependent?
• How do responses to acute challenge (e.g., injury, infection, etc.) and chronic diseases of the digestive organs present differently based on the sex of the organism?
• What are the critical gaps in understanding sex-dependent differences in digestive physiology and pathophysiology?
• How does sex affect the development of cancers in the digestive organs?
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• Article types: Research Articles, Short Reports, Methods and Resources, Perspectives, and Reviews
  
• Topics:

Sex similarities and differences in:

• Development of cardiovascular disease.
• Response to treatment for cardiovascular disease.
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• Article types: Research Articles, Short Reports, Methods and Resources, Perspectives and Reviews
  
• Topics:

Sex similarities and differences in:

• Studies to define sex-related differences in early life and adult respiratory health and disease following maternal and developmental exposures.
• Investigation of sex chromosome-mediated basis of respiratory function and disease risk.
• Studies identifying sex-specific mechanisms that underpin respiratory development, physiology and pathobiology.
• Effects of sex steroids on chronic respiratory diseases, including immune cell function and lung inflammation.
• In vitro investigation of cell sex as a determinant of cellular function.
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• Article types: Research Articles, Short Reports, Methods and Resources, Perspectives and Reviews
  
• Topics:

• Sex differences in autonomic nervous system regulation.
• The impact of sex on the development of obesity and metabolic diseases.
• Divergence in athletic performance and integrative response to exercise between males and females.
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• Article types: Research Articles, Short Reports, Methods and Resources, Perspectives, and Reviews
  
• Topics:
• The impact of testosterone of muscle growth properties and exercise performance (what is the impact of gender-affirming hormone therapy on exercise physiology?).
• Sex differences in responses to exercise and exercise interventions targeting brain health.
• Where do nonbinary human subjects fit in?
• Human data sets combining men and women—learning from the variability.
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• Article types: Research Articles, Short Reports, Methods and Resources, Perspectives, and Reviews
  
• Topics:
• Effects of sex steroids on nervous system functions.
  
• Sex-specific differences in neurological disorders and their implications for women’s health.
• Sex-specific differences in neurodevelopment and the implications for understanding neurodevelopmental disorders.
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• Article types: Research Articles, Short Reports, Methods and Resources, Perspectives, and Reviews
  
• Topics:
• Emerging methodologies for dissecting the contribution of sex chromosomes versus hormonal signaling to physiology and disease.
• Statistical and quantitative methodologies for understanding sex-based differences.
• Mouse models for dissecting sex chromosome versus hormonal signaling on physiological processes.
• Novel models for investigating the effects of X chromosome inactivation on physiological processes.
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