Cover: The developmental origins of health and disease theory is based on evidence that a suboptimal environment during fetal and neonatal development can significantly impact the evolution of adult-onset disease, including hypertension. Both maternal and placental factors can independently or co-dependently influence the in utero environment of the offspring to affect its cardiovascular health later in life. There is evidence that epigenetic alterations may contribute to increased oxidative stress, altered renin-angiotensin system function, altered hypothalamic-pituitary axis function, heightened sympathetic responsiveness, and endothelial dysfunction (particularly as relates to the nitric pathways). These changes ultimately combine to result in dysfunction of the two major blood pressure regulatory systems, namely, the kidney and systemic vasculature. See Morton, Jude S., Christy-Lynn Cooke, and Sandra T. Davidge. Physiol Rev 96: 549–603, 2016.