American Journal of Physiology Regulatory, Integrative and Comparative Physiology

Successive sets of high-intensity bilateral leg press exercises do not appear to affect cerebral or systemic hemodynamic measures, given adequate recovery time. The menstrual cycle phase impacts the directional sensitivity of the cerebral pressure-flow relationship during high-intensity bilateral leg press exercises. During high-intensity bilateral leg press exercises, the cerebrovasculature appears to be more pressure passive in the mid-luteal phase of the menstrual cycle.

CeA CB1R knockdown increased spontaneous and WD-induced hypertonic saline intake, without significantly impacting water ingestion. In euhydrated rats, despite unaltered urinary volume, CB1R knockdown reduced urinary osmolality, and diminished urinary nitrate concentrations, suggesting reduced renal sodium excretion. No relevant changes were induced by CeA CB1R knockdown on urinary parameters following WD-induced rehydration, which is consistent with unaltered AVP and OT mRNA transcription and hormone release under the same experimental conditions.

The study evaluated whether centrally mediated thermoregulatory fatigue is provoked by prolonged exposure to uncompensable cold. Regardless of the severity of cold stressor, the ability to produce endogenous heat remains intact during prolonged iterative exposure to a high-heat loss environment.

The current investigation identifies that activation of the exercise pressor reflex (EPR) by hindlimb muscle contraction generates exaggerated pressor responses in a chronic kidney disease (CKD) animal model. This hypertensive response is accompanied by sympathetic overactivation during EPR stimulation, with both the muscle mechanoreflex activated by passive muscle stretch and the muscle metaboreflex stimulated by intra-arterial capsaicin administration, contributing to the heightened pressor effect. These findings suggest augmented EPR, mechanoreflex, and metaboreflex function in CKD.