Got Guts: Aryl hydrocarbon receptor (AhR) function is required for optimal interleukin-22 signaling in colonic epithelial stem cells - In this podcast, coauthors Dr. Huajun Han, and Prof. Robert S. Chapkin of Texas A&M University, discuss their recently published research "Loss of aryl hydrocarbon receptor suppresses the response of colonic epithelial cells to IL22 signaling by upregulating SOCS3" with Editor-in-Chief Prof. Mark Frey.
Read the article: 10.1152/ajpgi.00074.2021 [More]
“Got Guts: Lifting the Lid on Diarrheal Diseases -
Physiological Reviews In today’s episode Dr. Stephen Keely from the Royal College of Surgeons in Ireland and Prof Kim Barrett of the University of California, Davis talk about their recent review article “Mechanisms of Secretory Diarrhea” with Prof Mark Frey. They discuss why it is we need to talk more about diarrheal diseases, lift the lid on the complex cellular and molecular mechanisms involved, and look to where new therapeutics are likely to arise in the future. Read the article: 10.1152/ajpgi.00316.2021
Got Guts: Embracing our heterogeneity - In a rapidly evolving era of single cell technologies, the authors of "Stiffness is associated with hepatic stellate cell heterogeneity during liver fibrosis" explain the mechanism of an amplification loop during liver fibrosis. By deciphering how stiffness macro and microscopic heterogeneity promote differential gene expression in hepatic stellate cell sub-populations, the authors find a novel stiffness-promoted molecule involved in liver fibrosis progression.
Read the article: 10.1152/ajpgi.00254.2021
Got Guts: HOPX+ injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia
Get to know senior author Dr. Liara M. Gonzalez of North Carolina State University as she discusses the recently published paper entitled "HOPX+ injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia" with EIC Prof. Mark Frey.
Got Guts: A new approach to treat gastrointestinal motility disorders - In this podcast authors Dr. Daniel Poole and Dr. Simona Carbone of Monash University discuss their recent paper, where they investigated the therapeutic potential of a positive allosteric modulator to enhance endogenous delta-opioid receptor signaling in the gut. Take a listen today!
Use of Human Tissue Stem Cell-Derived Organoid Cultures to Model Enterohepatic Circulation – Blutt et al. (2021); 10.1152/ajpgi.00177.2021
Pregnancy-related plasticity of gastric vagal afferent signals in mice” by Li et al (2017); 10.1152/ajpgi.00357
Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome – Miousse et al. (2020); 10.1152/ajpgi.00351.2019
Enterotoxigenic Escherichia coli LT inhibits intestinal ascorbic acid uptake – Subramenium et al. (2019); 10.1152/ajpgi.00259.2018
Muscarinic suppression of ATP-sensitive K+ channels mediated by the M3/Gq/11/phospholipase C pathway contributes to mouse ileal smooth muscle contractions – Wang et al. (2018); 10.1152/ajpgi.00069.2018
A novel bioluminescence-based method to investigate uptake of bile acids in living cells – Ticho et al. (2018); 10.1152/ajpgi.00133.2018
Effect of Lactobacillus reuteri is mediated by TLR2 – Hoang et al. (2018) - Hoang et al. (2017); 10.1152/ajpgi.00084.2017
Mucosal gene expression in irritable bowel syndrome with constipation – Videlock et al. (2018); 10.1152/ajpgi.00288.2017
Human placental-derived stem cell therapy ameliorates experimental necrotizing enterocolitis – Weis et al. (2021); 10.1152/ajpgi.00369.2020