- Shefaa AlAsfoor,
- Erik Jessen,
- Suraj R. Pullapantula,
- Jennifer R. Voisin,
- Linda C. Hsi,
- Kevin D. Pavelko,
- Samera Farwana,
- Jack A. Patraw,
- Xin-yi Chai,
- Sihan Ji,
- Michael A. Strausbauch,
- Gianluca Cipriani,
- Lai Wei,
- David R. Linden,
- Ruixue Hou,
- Richard Myers,
- Yogesh Bhattarai,
- Jill Wykosky,
- Alan J. Burns,
- Surendra Dasari,
- Gianrico Farrugia,
- Madhusudan Grover
https://doi.org/10.1152/ajpgi.00229.2024
Using 32 immune cell surface markers, we identified 23 monocyte clusters in murine blood. Diabetic gastroparesis was associated with a significant decrease in two circulating classical monocyte-like clusters and an upregulation of the Ccr2-Ccl2 axis in the gastric muscularis propria, suggesting increased tissue monocyte migration. This study offers new targets by pointing to a possible role for two classical monocyte subsets connected to the Ccr2-Ccl2 axis.