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American Journal of Physiology-Cell Physiology

31 Dec 2025

Role of versican in extracellular matrix formation: analysis in 3D culture

American Journal of Physiology-Cell Physiology

30 Dec 2025

Proteomic and phosphoproteomic identified structural and functional changes in the aorta associate with age-dependent hypertension in male Sprague-Dawley rats

Physiological Genomics

23 Dec 2024

Maternal-fetal interfaces transcriptome changes associated with placental insufficiency and a novel gene therapy intervention

Physiological Genomics

American Journal of Physiology-Renal Physiology

26 Dec 2024

A brief history of the cortical thick ascending limb: a systems-biology perspective

American Journal of Physiology-Renal Physiology

American Journal of Physiology-Endocrinology and Metabolism

31 Dec 2025

Species differences of fatty liver diseases: comparisons between human and feline

American Journal of Physiology-Endocrinology and Metabolism

26 Dec 2024

STIM1 and lipid interactions at ER-PM contact sites

American Journal of Physiology-Cell Physiology

25 Nov 2024

Terra incognita of the uncontrolled manifold

Journal of Neurophysiology

26 Nov 2024

Neuroscience of the human thalamus related to acute pain and chronic “thalamic” pain

Journal of Neurophysiology

31 Dec 2025

Sympathetic NPY boosts thermogenic adipocytes

American Journal of Physiology-Endocrinology and Metabolism

12 Dec 2024

Physiology in Perspective

Physiology

9 Dec 2024

Carbon monoxide inhalation for performance: dancing with the devil?

Journal of Applied Physiology

Altitude training is a cornerstone for endurance athletes for improving blood variables and performance, with optimal effects observed at ∼2,300–2,500 meters above sea level (m.a.s.l.). However, elite cyclists face challenges such as limited access to such altitudes, inadequate training facilities, and high expenses. To address these issues, a novel method involving daily exposure to carbon monoxide (CO) has been proposed to amplify altitude training adaptations at suboptimal altitudes. Thirty-one male cyclists were assigned to three groups: Live-High Train-High with CO inhalation (LHTHCO), Live-High Train-High (LHTH), and Live-Low Train-Low (LLTL). The LHTHCO group underwent CO inhalation twice daily in the afternoon/evening to elevate carboxyhemoglobin concentration to ∼10%. Hematological variables, in vivo muscle oxidative capacity, and physiological indicators of cycling performance were assessed before and after a 3-week altitude training camp at 2,100 m.a.s.l. LHTHCO demonstrated a larger increase in hemoglobin mass (Hbmass) compared to both LHTH and LLTL. Although there were no statistical differences between LHTHCO and LHTH in submaximal and maximal performance measures, LHTHCO displayed greater improvements in 1-min maximal power output during incremental testing (Wmax), power output at lactate threshold, and maximal oxygen consumption (V̇o2max) compared to LLTL. LHTH demonstrated a larger improvement than LLTL in Wmax and V̇o2max, with no group differences in Hbmass or submaximal measures. Muscle oxidative capacity did not differ between groups. These findings suggest that combining moderate-altitude training with daily CO inhalation promotes hematological adaptations more effectively than moderate altitude alone and enhances cycling performance metrics in cyclists more than sea-level training.NEW & NOTEWORTHY Three weeks of training at moderate altitude with exposure to low doses of CO can significantly enhance hematological adaptations in elite cyclists compared to moderate-altitude training alone. Cycling performance determinants improved more with CO inhalation at moderate altitude compared to sea-level training, whereas there were no differences in submaximal and maximal performance measures compared to moderate-altitude training alone. This study highlights the potential of CO supplementation as an effective adjunct to altitude training regimens.

9 Dec 2024

Advancements and future directions in American Journal of Physiology-Cell Physiology: a 2024 editorial update

American Journal of Physiology-Cell Physiology

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

23 Jan 2025

Swimming induces physiological cardioprotection associated with pro-growth versus anti-inflammatory influences in extracardiac organs

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

22 Jan 2025

Gut-kidney interaction reinforces dapagliflozin-mediated alleviation in diabetic nephropathy

American Journal of Physiology-Cell Physiology

23 Jan 2025

“The Mystery of the Cell Kingdom”: an online game to improve the learning of thyroid physiology

Advances in Physiology Education

17 Jan 2025

The serotonergic psychedelic DOI impairs deviance detection in the auditory cortex

Journal of Neurophysiology

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21 Dec 2023

Fiber-type traps: revisiting common misconceptions about skeletal muscle fiber types with application to motor control, biomechanics, physiology, and biology

Journal of Applied Physiology

21 Dec 2023

Guidelines on the use of sex and gender in cardiovascular research

American Journal of Physiology-Heart and Circulatory Physiology

16 Oct 2023

Recent insights into channelopathies

Physiological Reviews

21 Dec 2023

The effect of acute and 14-day exogenous ketone supplementation on glycemic control in adults with type 2 diabetes: two randomized controlled trials

American Journal of Physiology-Endocrinology and Metabolism

20 Dec 2023

Acute high-dose MitoQ does not increase urinary kidney injury markers in healthy adults: a randomized crossover trial

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